Biotechnology and Drug Discovery Services

Lead Discovery and Optimization Framework

Assay
Development

Target(s)
Scalability
Off Target Activity

Screen
Development

Readout
Scalability
Sample Testing

Screening

Scale up (HTS)
Automation
Data Management

Lead
Identification

Pharmacokinetics Toxicity
Info. Management

Lead
Optimization

Med. Chemistry
Toxicity
info. Management

Strategic Decisions

Governance Management

Novelty
Enhanced Activity

Hit Rate
Controls

Reproducibility
Hit Identification

Literature
Patentability

Compound
Management

Iterative Discover and Optimization

Lead Discovery and Optimization Delivery Methodology

Establish (Plan)

Implement and Operation (Do)

Monitor and Review (Check)

Maintain and Improve (Act)

Plan Phase

  • Evaluate market opportunities
  • Define target(s) and molecule class
  • Establish proof of concept (POC)
    • Assay
    • Readout
  • Develop screening strategy

Do Phase

  • Perform POC
  • Implement strategies for screening
    • Scalability
    • Metrics
  • Hit Selection
  • Lead selection
  • Lead optimization

Check Phase

  • Critical path
    • Toxicity
    • Mode of action
    • Off-target activity
  • Medicinal Chemistry
    • Lead optimization
  • Project Team review

Act Phase

  • Management adjusts program as per market opportunity
  • Management reviews program (go/ no go)